{"id":1360,"date":"2016-02-29T14:44:08","date_gmt":"2016-02-29T13:44:08","guid":{"rendered":"https:\/\/ngm-cancer.fraujacobi.de\/en\/?page_id=1360"},"modified":"2016-03-17T08:44:54","modified_gmt":"2016-03-17T07:44:54","slug":"new-therapeutic-approaches-from-genomic-research","status":"publish","type":"page","link":"https:\/\/ngm-cancer.fraujacobi.de\/en\/new-therapeutic-approaches-from-genomic-research\/","title":{"rendered":"New therapeutic approaches from genomic research"},"content":{"rendered":"

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[\/et_pb_post_title][et_pb_text admin_label=”Text” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid”]<\/p>\n

More recently, the biology of the lung cancer disease is becoming better understood by advances in genomics. It is apparent that lung cancer is composed of a plurality of subsets, which are characterized by specific molecular changes.<\/p>\n

These genetic changes (known as mutations, amplifications, or gene fusions) are responsible for ensuring that the tumor cells show a malignant growth, therefore they are also called driver mutations. By means of targeted drugs (kinase inhibitors, antibodies) they can be inhibited.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Text” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid”]<\/p>\n

This “personalized” treatment is often much more effective (higher tumor shrinkage rate, longer survival) and better tolerated than chemotherapy. Although such driver mutations can be found in approximately half of all patients with lung cancer, already approved targeted drugs are only available for a minor part of them. This involves genetic alterations in the EGFR-receptor, the ALK-gene and the ROS-gene. For more driver mutations there is the possibility to participate in clinical trials<\/a>. Currently, all therapeutically treatable driver mutations belong to the group of adenocarcinoma, for the squamous cell carcinoma and the small cell lung cancer there are no personalized therapeutic approaches available yet.<\/p>\n

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Last update: 17. March 2016 , 8:44<\/span><\/em><\/p>\n

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[\/et_pb_sidebar][\/et_pb_column][\/et_pb_section][et_pb_section admin_label=”section” global_module=”1336″ fullwidth=”off” transparent_background=”off” background_color=”#eeeeee” allow_player_pause=”off” inner_shadow=”off” parallax=”on” parallax_method=”on” padding_mobile=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” gutter_width=”3″ background_image=”https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2015\/12\/291_ngm_BG-t5.png”][et_pb_row global_parent=”1336″ admin_label=”row” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” gutter_width=”3″ padding_mobile=”off” allow_player_pause=”off” parallax=”off” parallax_method=”on” make_equal=”on” parallax_1=”off” parallax_method_1=”off” background_color_1=”#ffffff” padding_top_1=”50px” padding_right_1=”32px” padding_bottom_1=”50px” padding_left_1=”32px” parallax_2=”off” parallax_method_2=”off” background_color_2=”#ffffff” padding_top_2=”50px” padding_right_2=”32px” padding_bottom_2=”50px” padding_left_2=”32px” parallax_3=”off” parallax_method_3=”off” background_color_3=”#ffffff” padding_top_3=”50px” padding_right_3=”32px” padding_bottom_3=”50px” padding_left_3=”32px” column_padding_mobile=”on” module_id=”pseudofooter-row”][et_pb_column type=”1_3″][et_pb_blurb global_parent=”1336″ admin_label=”Molekulare Diagnostik” title=”Molecular diagnostics” url_new_window=”off” animation=”off” background_layout=”light” text_orientation=”center” icon_placement=”top” font_icon=”%%103%%” use_icon=”on” use_circle=”off” use_circle_border=”off” icon_color=”#3b78aa” circle_color=”#81d742″ circle_border_color=”#2caaca” url=”\/?p=74\/” use_icon_font_size=”off” use_border_color=”off” border_color=”#ffffff” border_style=”solid” header_line_height=”1.5em”]<\/p>\n

As the first group in Europe, the Network Genomic Medicine has offered a comprehensive analysis of tumor material since 2012. By means of a multiplex-test in combination with highly sensitive deep sequencing even rare gene mutations in the smallest tissue samples are detected reliably<\/p>\n

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[\/et_pb_divider][et_pb_cta global_parent=”1336″ admin_label=”Diagnostik” button_url=”https:\/\/ngm-cancer.fraujacobi.de\/en\/diagnostics\/” url_new_window=”off” button_text=”Diagnostics” use_background_color=”off” background_color=”#4d9acf” background_layout=”light” text_orientation=”center” use_border_color=”off” border_color=”#ffffff” border_style=”solid” custom_button=”off” button_text_size=”16″ button_border_radius=”0″ button_letter_spacing=”0″ button_use_icon=”default” button_icon_placement=”right” button_on_hover=”on” button_border_radius_hover=”0″ button_letter_spacing_hover=”0″]<\/p>\n

[\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_3″][et_pb_blurb global_parent=”1336″ admin_label=”Second opinion” title=”Second opinion” url_new_window=”off” animation=”off” background_layout=”light” text_orientation=”center” icon_placement=”top” font_icon=”%%86%%” use_icon=”on” use_circle=”off” use_circle_border=”off” icon_color=”#3b78aa” circle_color=”#999999″ circle_border_color=”#2caaca” url=”\/?p=76\/” use_icon_font_size=”off” use_border_color=”off” border_color=”#ffffff” border_style=”solid” header_line_height=”1.5em”]<\/p>\n

Do you have questions about your disease or your current therapy? Or maybe you would like to know if for you a personalized treatment approach or immunotherapy might be considered. Please feel free to contact us!<\/p>\n

[\/et_pb_blurb][et_pb_divider global_parent=”1336″ admin_label=”Teiler” color=”#ffffff” show_divider=”off” height=”53″ divider_style=”solid” divider_position=”top” hide_on_mobile=”on”]<\/p>\n

[\/et_pb_divider][et_pb_cta global_parent=”1336″ admin_label=”Zweitmeinung” button_url=”https:\/\/ngm-cancer.fraujacobi.de\/en\/second-opinion-service\/” url_new_window=”off” button_text=”Second Opinion” use_background_color=”off” background_color=”#4d9acf” background_layout=”light” text_orientation=”center” use_border_color=”off” border_color=”#ffffff” border_style=”solid” custom_button=”off” button_text_size=”16″ button_border_radius=”0″ button_letter_spacing=”0″ button_use_icon=”default” button_icon_placement=”right” button_on_hover=”on” button_border_radius_hover=”0″ button_letter_spacing_hover=”0″]<\/p>\n

[\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_3″][et_pb_blurb global_parent=”1336″ admin_label=”Clinical trials” title=”Clinical trials” url_new_window=”off” animation=”off” background_layout=”light” text_orientation=”center” icon_placement=”top” font_icon=”%%77%%” use_icon=”on” use_circle=”off” use_circle_border=”off” icon_color=”#3b78aa” circle_color=”#81d742″ circle_border_color=”#2caaca” url=”\/?p=76\/” use_icon_font_size=”off” use_border_color=”off” border_color=”#ffffff” border_style=”solid” header_line_height=”1.5em”]<\/p>\n

At the Network Genomic Medicine we try to offer an appropriate clinical trial testing a new drug to all our patients who have a detected mutation, for which there has no drug been approved for treatment yet. For that we work closely together with the Lung Cancer Group Cologne.<\/p>\n

[\/et_pb_blurb][et_pb_divider global_parent=”1336″ admin_label=”Teiler” color=”#ffffff” show_divider=”off” height=”2″ divider_style=”solid” divider_position=”top” hide_on_mobile=”on”]<\/p>\n

[\/et_pb_divider][et_pb_cta global_parent=”1336″ admin_label=”Studien” button_url=”https:\/\/ngm-cancer.fraujacobi.de\/en\/clinical-trials\/” url_new_window=”off” button_text=”Trials” use_background_color=”off” background_color=”#4d9acf” background_layout=”light” text_orientation=”center” use_border_color=”off” border_color=”#ffffff” border_style=”solid” custom_button=”off” button_text_size=”16″ button_border_radius=”0″ button_letter_spacing=”0″ button_use_icon=”default” button_icon_placement=”right” button_on_hover=”on” button_border_radius_hover=”0″ button_letter_spacing_hover=”0″]<\/p>\n

[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

More recently, the biology of the lung cancer disease is becoming better understood by advances in genomics. It is apparent that lung cancer is composed of a plurality of subsets, which are characterized by specific molecular changes. These genetic changes (known as mutations, amplifications, or gene fusions) are responsible for ensuring that the tumor cells […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":0,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section admin_label=\"Sektion\" global_module=\"1240\" fullwidth=\"on\" specialty=\"off\" transparent_background=\"off\" allow_player_pause=\"off\" inner_shadow=\"off\" parallax=\"off\" parallax_method=\"off\" padding_mobile=\"off\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"on\" make_equal=\"off\" use_custom_gutter=\"off\"][et_pb_fullwidth_slider global_parent=\"1240\" admin_label=\"Vollbreiter Slider\" show_arrows=\"on\" show_pagination=\"on\" auto=\"off\" auto_ignore_hover=\"off\" parallax=\"off\" parallax_method=\"off\" remove_inner_shadow=\"off\" background_position=\"default\" background_size=\"default\" hide_content_on_mobile=\"off\" hide_cta_on_mobile=\"off\" show_image_video_mobile=\"off\" custom_button=\"off\" button_border_radius=\"0\" button_letter_spacing=\"0\" button_use_icon=\"default\" button_icon_placement=\"right\" button_on_hover=\"on\" button_border_radius_hover=\"0\" button_letter_spacing_hover=\"0\" custom_css_main_element=\"height:450px;\" custom_css_slide_description=\"height:450px;\"] [et_pb_slide background_image=\"https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2015\/12\/stock-photo-74518125-doctor-hand-with-prostate-cancer-awareness-ribbon.jpg\" background_position=\"default\" background_size=\"default\" background_color=\"#ffffff\" use_bg_overlay=\"off\" use_text_overlay=\"off\" alignment=\"center\" background_layout=\"dark\" allow_player_pause=\"off\" text_border_radius=\"3\" header_font_select=\"default\" header_font=\"||||\" body_font_select=\"default\" body_font=\"||||\" custom_button=\"off\" button_font_select=\"default\" button_font=\"||||\" button_use_icon=\"default\" button_icon_placement=\"right\" button_on_hover=\"on\"] [\/et_pb_slide][et_pb_slide background_image=\"https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2016\/02\/stock-photo-77019281-nurse-holding-patient-s-hand.jpg\" background_position=\"default\" background_size=\"default\" background_color=\"#ffffff\" use_bg_overlay=\"off\" use_text_overlay=\"off\" alignment=\"center\" background_layout=\"dark\" allow_player_pause=\"off\" text_border_radius=\"3\" header_font_select=\"default\" header_font=\"||||\" body_font_select=\"default\" body_font=\"||||\" custom_button=\"off\" button_font_select=\"default\" button_font=\"||||\" button_use_icon=\"default\" button_icon_placement=\"right\" button_on_hover=\"on\"] [\/et_pb_slide][et_pb_slide background_image=\"https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2016\/02\/stock-photo-72988469-close-up-of-hands-with-cancer-awareness-symbol.jpg\" background_position=\"default\" background_size=\"default\" background_color=\"#ffffff\" use_bg_overlay=\"off\" use_text_overlay=\"off\" alignment=\"center\" background_layout=\"dark\" allow_player_pause=\"off\" text_border_radius=\"3\" header_font_select=\"default\" header_font=\"||||\" body_font_select=\"default\" body_font=\"||||\" custom_button=\"off\" button_font_select=\"default\" button_font=\"||||\" button_use_icon=\"default\" button_icon_placement=\"right\" button_on_hover=\"on\"] [\/et_pb_slide] [\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section admin_label=\"Sektion\" fullwidth=\"off\" specialty=\"on\"][et_pb_column type=\"3_4\" specialty_columns=\"3\"][et_pb_row_inner admin_label=\"Zeile\"][et_pb_column_inner type=\"4_4\" saved_specialty_column_type=\"3_4\"][et_pb_post_title admin_label=\"Posttitel\" title=\"on\" meta=\"off\" author=\"on\" date=\"on\" categories=\"on\" comments=\"on\" featured_image=\"off\" featured_placement=\"below\" parallax_effect=\"on\" parallax_method=\"on\" text_orientation=\"left\" text_color=\"dark\" text_background=\"off\" text_bg_color=\"rgba(255,255,255,0.9)\" module_bg_color=\"rgba(255,255,255,0)\" title_all_caps=\"off\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\"] [\/et_pb_post_title][et_pb_text admin_label=\"Text\" background_layout=\"light\" text_orientation=\"left\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\"]\r\n\r\nIn j\u00fcngerer Zeit wird die Biologie der Erkrankung Lungenkrebs durch Fortschritte in der Genomforschung immer besser verstanden. Es wird deutlich, dass Lungenkrebs aus einer Vielzahl von Untergruppen besteht, die durch bestimmte molekulare Ver\u00e4nderungen charakterisiert sind.\r\n\r\nDiese genetischen Ver\u00e4nderungen (sogenannte Mutationen, Amplifikationen oder Genfusionen) sind daf\u00fcr verantwortlich, dass die Tumorzellen ein b\u00f6sartiges Wachstum zeigen, man nennt sie daher auch Treibermutationen. Durch zielgerichtete Medikamente (Kinaseinhibitoren, Antik\u00f6rper) k\u00f6nnen sie gehemmt werden. Diese \u201epersonalisierte\u201c Therapie ist oft wesentlich wirksamer (h\u00f6here Tumorschrumpfungsrate, l\u00e4ngeres \u00dcberleben) und besser vertr\u00e4glich als Chemotherapie. Obwohl man bei ungef\u00e4hr der H\u00e4lfte aller Lungenkrebspatienten solche Treibermutationen findet, gibt es nur f\u00fcr einen kleineren Teil bereits zugelassene zielgerichtete Medikamente. Hierbei handelt es sich um genetische Ver\u00e4nderungen im EGFR-Rezeptor, dem ALK-Gen und dem ROS Gen. F\u00fcr weitere Treibermutationen gibt es die M\u00f6glichkeit, an klinischen Studien<\/a> teilzunehmen. Aktuell finden sich alle therapeutisch angehbaren Treibermutationen in der Gruppe der Adenokarzinome f\u00fcr das Plattenepithelkarzinom und das kleinzellige Bronchialkarzinom gibt es noch keine personalisierten Therapieans\u00e4tze.\r\n\r\n[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=\"Zeile\"][et_pb_column_inner type=\"4_4\" saved_specialty_column_type=\"3_4\"][et_pb_text admin_label=\"Letzte \u00c4nderung\" global_module=\"1196\" saved_tabs=\"all\" background_layout=\"light\" text_orientation=\"left\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" module_class=\"content-update\"]\r\n\r\nLetzte \u00c4nderung: [last-modified datef='d. F Y' sep=',']<\/em>\r\n

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=\"1_4\"][et_pb_sidebar admin_label=\"Seitenleiste\" orientation=\"right\" area=\"et_pb_widget_area_6\" background_layout=\"light\" remove_border=\"off\"] [\/et_pb_sidebar][\/et_pb_column][\/et_pb_section][et_pb_section admin_label=\"section\" global_module=\"309\" fullwidth=\"off\" transparent_background=\"off\" background_color=\"#eeeeee\" allow_player_pause=\"off\" inner_shadow=\"off\" parallax=\"on\" parallax_method=\"on\" padding_mobile=\"off\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"on\" make_equal=\"off\" use_custom_gutter=\"off\" gutter_width=\"3\" background_image=\"https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2015\/12\/291_ngm_BG-t5.png\"][et_pb_row global_parent=\"309\" admin_label=\"row\" make_fullwidth=\"off\" use_custom_width=\"off\" width_unit=\"on\" use_custom_gutter=\"off\" gutter_width=\"3\" padding_mobile=\"off\" allow_player_pause=\"off\" parallax=\"off\" parallax_method=\"on\" make_equal=\"on\" parallax_1=\"off\" parallax_method_1=\"off\" background_color_1=\"#ffffff\" padding_top_1=\"50px\" padding_right_1=\"32px\" padding_bottom_1=\"50px\" padding_left_1=\"32px\" parallax_2=\"off\" parallax_method_2=\"off\" background_color_2=\"#ffffff\" padding_top_2=\"50px\" padding_right_2=\"32px\" padding_bottom_2=\"50px\" padding_left_2=\"32px\" parallax_3=\"off\" parallax_method_3=\"off\" background_color_3=\"#ffffff\" padding_top_3=\"50px\" padding_right_3=\"32px\" padding_bottom_3=\"50px\" padding_left_3=\"32px\" column_padding_mobile=\"on\" module_id=\"pseudofooter-row\"][et_pb_column type=\"1_3\"][et_pb_blurb global_parent=\"309\" admin_label=\"Molekulare Diagnostik\" title=\"Molekulare Diagnostik\" url_new_window=\"off\" animation=\"off\" background_layout=\"light\" text_orientation=\"center\" icon_placement=\"top\" font_icon=\"%%103%%\" use_icon=\"on\" use_circle=\"off\" use_circle_border=\"off\" icon_color=\"#3b78aa\" circle_color=\"#81d742\" circle_border_color=\"#2caaca\" url=\"\/?p=74\/\" use_icon_font_size=\"off\" header_font_size=\"18\" body_font_size=\"14\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" header_line_height=\"1.5em\"]<\/p>\r\nDas Netzwerk Genomische Medizin bietet eine umfassende molekulare Analyse von Tumorproben an. Mittels eines Next Generation Sequencing basierten Multiplex-Verfahrens werden s\u00e4mtliche therapierelevanten genomischen Ver\u00e4nderungen auch in kleinsten Gewebeproben zuverl\u00e4ssig detektiert.\r\n

[\/et_pb_blurb][et_pb_divider global_parent=\"309\" admin_label=\"Teiler\" color=\"#ffffff\" show_divider=\"off\" divider_style=\"solid\" divider_position=\"top\" divider_weight=\"1\" hide_on_mobile=\"on\" height=\"2\"] [\/et_pb_divider][et_pb_cta global_parent=\"309\" admin_label=\"Diagnostik\" button_url=\"\/?p=74\/\" url_new_window=\"off\" button_text=\"Diagnostik\" use_background_color=\"off\" background_color=\"#4d9acf\" background_layout=\"light\" text_orientation=\"center\" header_font_size=\"26\" body_font_size=\"14\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" custom_button=\"off\" button_text_size=\"16\" button_border_width=\"2\" button_border_radius=\"0\" button_letter_spacing=\"0\" button_use_icon=\"default\" button_icon_placement=\"right\" button_on_hover=\"on\" button_border_radius_hover=\"0\" button_letter_spacing_hover=\"0\"] [\/et_pb_cta][\/et_pb_column][et_pb_column type=\"1_3\"][et_pb_blurb global_parent=\"309\" admin_label=\"Zweitmeinung\" title=\"Zweitmeinung\" url_new_window=\"off\" animation=\"off\" background_layout=\"light\" text_orientation=\"center\" icon_placement=\"top\" font_icon=\"%%86%%\" use_icon=\"on\" use_circle=\"off\" use_circle_border=\"off\" icon_color=\"#3b78aa\" circle_color=\"#999999\" circle_border_color=\"#2caaca\" url=\"\/?p=76\/\" use_icon_font_size=\"off\" header_font_size=\"18\" body_font_size=\"14\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" header_line_height=\"1.5em\"]<\/p>\r\nHaben Sie Fragen zu Ihrer Erkrankung, Ihrer bestehenden Therapie oder vielleicht m\u00f6chten Sie auch wissen, ob f\u00fcr Sie ein personalisierter Therapieansatz oder eine Immuntherapie in Frage kommt?\r\n\r\nKontaktieren Sie uns!\r\n

[\/et_pb_blurb][et_pb_divider global_parent=\"309\" admin_label=\"Teiler\" color=\"#ffffff\" show_divider=\"off\" height=\"32\" divider_style=\"solid\" divider_position=\"top\" divider_weight=\"1\" hide_on_mobile=\"on\"] [\/et_pb_divider][et_pb_cta global_parent=\"309\" admin_label=\"Zweitmeinung\" button_url=\"\/?p=76\/\" url_new_window=\"off\" button_text=\"Zweitmeinung\" use_background_color=\"off\" background_color=\"#4d9acf\" background_layout=\"light\" text_orientation=\"center\" header_font_size=\"26\" body_font_size=\"14\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" custom_button=\"off\" button_text_size=\"16\" button_border_width=\"2\" button_border_radius=\"0\" button_letter_spacing=\"0\" button_use_icon=\"default\" button_icon_placement=\"right\" button_on_hover=\"on\" button_border_radius_hover=\"0\" button_letter_spacing_hover=\"0\"] [\/et_pb_cta][\/et_pb_column][et_pb_column type=\"1_3\"][et_pb_blurb global_parent=\"309\" admin_label=\"Klinische Studien\" title=\"Klinische Studien\" url_new_window=\"off\" animation=\"off\" background_layout=\"light\" text_orientation=\"center\" icon_placement=\"top\" font_icon=\"%%77%%\" use_icon=\"on\" use_circle=\"off\" use_circle_border=\"off\" icon_color=\"#3b78aa\" circle_color=\"#81d742\" circle_border_color=\"#2caaca\" url=\"\/?p=76\/\" use_icon_font_size=\"off\" header_font_size=\"18\" body_font_size=\"14\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\" header_line_height=\"1.5em\"]<\/p>\r\nInnerhalb des Netzwerks Genomische Medizin wollen wir allen Patienten mit einer Mutation, f\u00fcr die es noch kein zugelassenes Medikament gibt, eine klinische Studie anbieten.\r\n\r\nInformieren Sie sich hier, welche aktuellen Studien es gibt.\r\n

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