{"id":1377,"date":"2016-03-01T10:34:59","date_gmt":"2016-03-01T09:34:59","guid":{"rendered":"https:\/\/ngm-cancer.fraujacobi.de\/en\/?page_id=1377"},"modified":"2016-03-01T11:05:16","modified_gmt":"2016-03-01T10:05:16","slug":"what-is-a-clinical-trial","status":"publish","type":"page","link":"https:\/\/ngm-cancer.fraujacobi.de\/en\/clinical-trials\/what-is-a-clinical-trial\/","title":{"rendered":"What is a clinical trial?"},"content":{"rendered":"<p>[et_pb_section admin_label=&#8221;Sektion&#8221; global_module=&#8221;1249&#8243; fullwidth=&#8221;on&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;off&#8221; padding_mobile=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221;][et_pb_fullwidth_slider global_parent=&#8221;1249&#8243; admin_label=&#8221;Vollbreiter Slider&#8221; show_arrows=&#8221;on&#8221; show_pagination=&#8221;on&#8221; auto=&#8221;off&#8221; auto_ignore_hover=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;off&#8221; remove_inner_shadow=&#8221;off&#8221; background_position=&#8221;default&#8221; background_size=&#8221;default&#8221; hide_content_on_mobile=&#8221;off&#8221; hide_cta_on_mobile=&#8221;off&#8221; show_image_video_mobile=&#8221;off&#8221; custom_button=&#8221;off&#8221; button_border_radius=&#8221;0&#8243; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_border_radius_hover=&#8221;0&#8243; button_letter_spacing_hover=&#8221;0&#8243; custom_css_main_element=&#8221;height:450px;&#8221; custom_css_slide_image=&#8221;height:450px;&#8221; custom_css_slide_description=&#8221;height:450px;&#8221;]<\/p>\n<p>[et_pb_slide background_image=&#8221;https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2016\/01\/LCGC-Team.jpg&#8221; background_position=&#8221;default&#8221; background_size=&#8221;default&#8221; background_color=&#8221;#ffffff&#8221; use_bg_overlay=&#8221;off&#8221; use_text_overlay=&#8221;off&#8221; alignment=&#8221;center&#8221; background_layout=&#8221;dark&#8221; allow_player_pause=&#8221;off&#8221; text_border_radius=&#8221;3&#8243; header_font_select=&#8221;default&#8221; header_font=&#8221;||||&#8221; body_font_select=&#8221;default&#8221; body_font=&#8221;||||&#8221; custom_button=&#8221;off&#8221; button_font_select=&#8221;default&#8221; button_font=&#8221;||||&#8221; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221;]<\/p>\n<p>[\/et_pb_slide]<\/p>\n<p>[\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section admin_label=&#8221;Sektion&#8221; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221;][et_pb_column type=&#8221;3_4&#8243; specialty_columns=&#8221;3&#8243;][et_pb_row_inner admin_label=&#8221;Zeile&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_post_title admin_label=&#8221;Posttitel&#8221; title=&#8221;on&#8221; meta=&#8221;off&#8221; author=&#8221;on&#8221; date=&#8221;on&#8221; categories=&#8221;on&#8221; comments=&#8221;on&#8221; featured_image=&#8221;off&#8221; featured_placement=&#8221;below&#8221; parallax_effect=&#8221;on&#8221; parallax_method=&#8221;on&#8221; text_orientation=&#8221;left&#8221; text_color=&#8221;dark&#8221; text_background=&#8221;off&#8221; text_bg_color=&#8221;rgba(255,255,255,0.9)&#8221; module_bg_color=&#8221;rgba(255,255,255,0)&#8221; title_all_caps=&#8221;off&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<p>[\/et_pb_post_title][et_pb_text admin_label=&#8221;Text&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<p>Usually drugs or drug combinations which have not yet been approved for the respective disease are tested in clinical trials. Likewise drugs may be tested which, while approved for certain diseases, are not approved for the disease from which patients are suffering in that trial.<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Zeile&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_text admin_label=&#8221;Text&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<h3>Trials generally undergo 4 phases.<\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Zeile&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_toggle admin_label=&#8221;Umschalter&#8221; title=&#8221;Phase 1&#8243; open=&#8221;off&#8221; closed_toggle_background_color=&#8221;#3b78aa&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; closed_toggle_text_color=&#8221;#ffffff&#8221; title_font_size=&#8221;20&#8243; custom_css_toggle_title=&#8221;text-align:center;&#8221; open_toggle_background_color=&#8221;#3b78aa&#8221; open_toggle_text_color=&#8221;#ffffff&#8221; icon_color=&#8221;#ffffff&#8221; title_text_color=&#8221;#ffffff&#8221; body_text_color=&#8221;#ffffff&#8221;]<\/p>\n<ul>\n<li>the drug is used in humans for the first time (first-in-man),<\/li>\n<li>All patients participating in the study generally receive the drug with the active ingredient. This phase is about gaining important data on the safety and tolerability, to determine the optimal therapeutic dose and to get a first impression of the effectiveness of the therapy.<\/li>\n<li>Once this data is available, a drug can go into the second phase of testing.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle admin_label=&#8221;Umschalter&#8221; title=&#8221;Phase 2&#8243; open=&#8221;off&#8221; closed_toggle_background_color=&#8221;#3b78aa&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; closed_toggle_text_color=&#8221;#ffffff&#8221; title_font_size=&#8221;20&#8243; custom_css_toggle_title=&#8221;text-align:center;&#8221; open_toggle_background_color=&#8221;#3b78aa&#8221; open_toggle_text_color=&#8221;#ffffff&#8221; icon_color=&#8221;#ffffff&#8221; title_text_color=&#8221;#ffffff&#8221; body_text_color=&#8221;#ffffff&#8221;]<\/p>\n<ul>\n<li>the task is to gather further data on the efficacy of the drug and additional data on safety and tolerability.<\/li>\n<li>Usually, also in this study phase, all patients receive the drug to be tested. Rarely Phase II study are randomized,<\/li>\n<li>which means that some of the patients receive standard treatment while the other part receives the drug with the new active ingredient or the new combination.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][et_pb_toggle admin_label=&#8221;Umschalter&#8221; title=&#8221;Phase 3&#8243; open=&#8221;off&#8221; closed_toggle_background_color=&#8221;#3b78aa&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; closed_toggle_text_color=&#8221;#ffffff&#8221; title_font_size=&#8221;20&#8243; custom_css_toggle_title=&#8221;text-align:center;&#8221; open_toggle_background_color=&#8221;#3b78aa&#8221; open_toggle_text_color=&#8221;#ffffff&#8221; icon_color=&#8221;#ffffff&#8221; title_text_color=&#8221;#ffffff&#8221; body_text_color=&#8221;#ffffff&#8221;]<\/p>\n<ul>\n<li>Phase III is eventually about showing that the new drug is better or just as good as the standard therapy.<\/li>\n<li>These trials are always randomized. Randomization can be open (both, the patient and the physician know which drug the patient receives) or blinded (neither the doctor nor the patient knows which drug is given).<\/li>\n<li>Neither doctor nor patient have an influence in the decision over which treatment the patient will receive. The decision is subject to statistical calculations and is made by a computer system.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<h3 style=\"text-align: center;\"><span style=\"color: #ffffff;\">market approval<\/span><\/h3>\n<p style=\"text-align: center;\">Zulassungsantrag bei Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte (BfArM) nach Phase II und III. Erst nach Zulassung ist das Arzneimittel in der Apotheke erh\u00e4ltlich.<\/p>\n<p>[\/et_pb_toggle][et_pb_toggle admin_label=&#8221;Umschalter&#8221; title=&#8221;Phase 4&#8243; open=&#8221;off&#8221; closed_toggle_background_color=&#8221;#3b78aa&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; closed_toggle_text_color=&#8221;#ffffff&#8221; title_font_size=&#8221;20&#8243; custom_css_toggle_title=&#8221;text-align:center;&#8221; open_toggle_background_color=&#8221;#3b78aa&#8221; open_toggle_text_color=&#8221;#ffffff&#8221; icon_color=&#8221;#ffffff&#8221; title_text_color=&#8221;#ffffff&#8221; body_text_color=&#8221;#ffffff&#8221;]<\/p>\n<ul>\n<li>After admission<\/li>\n<li>Recognizing rare side effects<\/li>\n<li>Comparing the new medication to already existing medicine, gathering new information in a very big group of patients<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Zeile&#8221; padding_mobile=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; column_padding_mobile=&#8221;on&#8221; make_equal=&#8221;off&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; background_color_1=&#8221;#4d9acf&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; background_color_2=&#8221;#4d9acf&#8221; disabled_on=&#8221;on|on|on&#8221; disabled=&#8221;on&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_blurb admin_label=&#8221;Phase I&#8221; title=&#8221;Phase I&#8221; url_new_window=&#8221;off&#8221; use_icon=&#8221;off&#8221; icon_color=&#8221;#4d9acf&#8221; use_circle=&#8221;off&#8221; circle_color=&#8221;#4d9acf&#8221; use_circle_border=&#8221;off&#8221; circle_border_color=&#8221;#4d9acf&#8221; icon_placement=&#8221;top&#8221; animation=&#8221;top&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_icon_font_size=&#8221;off&#8221; header_font_size=&#8221;22&#8243; header_text_color=&#8221;#ffffff&#8221; body_font_size=&#8221;14&#8243; use_border_color=&#8221;off&#8221; border_color=&#8221;#4d9acf&#8221; border_style=&#8221;solid&#8221; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_parent=&#8221;301&#8243; body_text_color=&#8221;#ffffff&#8221; border_width=&#8221;2px&#8221; header_line_height=&#8221;1.7em&#8221;]<\/p>\n<ul>\n<li>Medikament wird zum ersten Mal im Menschen getestet (first-in-man),<\/li>\n<li>Datenerhebung zur Vertr\u00e4glichkeit des Arzneimittels und der Pharmakokinetik (wie sich der Stoff im K\u00f6rper verteilt, umabgebaut und ausgeschieden wird)<\/li>\n<li>Nur wenige Patienten<\/li>\n<\/ul>\n<p style=\"text-align: center;\">\n<p>[\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_blurb admin_label=&#8221;Phase II&#8221; title=&#8221;Phase II&#8221; url_new_window=&#8221;off&#8221; use_icon=&#8221;off&#8221; icon_color=&#8221;#4d9acf&#8221; use_circle=&#8221;off&#8221; circle_color=&#8221;#4d9acf&#8221; use_circle_border=&#8221;off&#8221; circle_border_color=&#8221;#4d9acf&#8221; icon_placement=&#8221;top&#8221; animation=&#8221;top&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_icon_font_size=&#8221;off&#8221; header_font_size=&#8221;22&#8243; body_font_size=&#8221;14&#8243; use_border_color=&#8221;off&#8221; border_color=&#8221;#4d9acf&#8221; border_style=&#8221;solid&#8221; global_parent=&#8221;301&#8243; header_text_color=&#8221;#ffffff&#8221; body_text_color=&#8221;#ffffff&#8221; border_width=&#8221;2px&#8221; custom_padding=&#8221;40px|40px|40px|40px&#8221; header_line_height=&#8221;1.7em&#8221;]<\/p>\n<ul>\n<li>Daten zur Wirksamkeit, Vertr\u00e4glichkeit und Sicherheit des Medikamentes evaluieren<\/li>\n<li>Ermittlung der optimalen Therapiedosis (verschiedene Gruppen von Patienten, jede bekommt einen andere Dosis)<\/li>\n<li>Mehrere hundert Patienten \u00fcber kurzen Behandlungszeitraum<\/li>\n<\/ul>\n<p style=\"text-align: center;\">\n<p>[\/et_pb_blurb][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Zeile&#8221; padding_mobile=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; column_padding_mobile=&#8221;on&#8221; make_equal=&#8221;off&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; background_color_1=&#8221;#4d9acf&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; background_color_2=&#8221;#4d9acf&#8221; disabled_on=&#8221;on|on|on&#8221; disabled=&#8221;on&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_blurb admin_label=&#8221;Phase III&#8221; title=&#8221;Phase III&#8221; url_new_window=&#8221;off&#8221; use_icon=&#8221;off&#8221; icon_color=&#8221;#4d9acf&#8221; use_circle=&#8221;off&#8221; circle_color=&#8221;#4d9acf&#8221; use_circle_border=&#8221;off&#8221; circle_border_color=&#8221;#4d9acf&#8221; icon_placement=&#8221;top&#8221; animation=&#8221;top&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_icon_font_size=&#8221;off&#8221; header_font_size=&#8221;22&#8243; body_font_size=&#8221;14&#8243; use_border_color=&#8221;off&#8221; border_color=&#8221;#4d9acf&#8221; border_style=&#8221;solid&#8221; global_parent=&#8221;301&#8243; header_text_color=&#8221;#ffffff&#8221; border_width=&#8221;2px&#8221; custom_padding=&#8221;40px|40px|40px|40px&#8221; header_line_height=&#8221;1.7em&#8221; body_text_color=&#8221;#ffffff&#8221;]<\/p>\n<ul>\n<li>Vergleich den neuen Arzneimittel mit dem Standard (oder eventl. Placebo)<\/li>\n<li>Randomisierung offen oder verblindet<\/li>\n<li>Erprobung des Arzneimittels in einer gr\u00f6\u00dferen Patientengruppe in der Anwendung \u00fcber l\u00e4ngere Zeit<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><strong>Marktzulassung<\/strong><\/p>\n<p style=\"text-align: center;\">Zulassungsantrag bei Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte (BfArM) nach Phase II und III. Erst nach Zulassung ist das Arzneimittel in der Apotheke erh\u00e4ltlich.<\/p>\n<p style=\"text-align: center;\">\n<p>[\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_blurb admin_label=&#8221;Phase IV&#8221; title=&#8221;Phase IV&#8221; url_new_window=&#8221;off&#8221; use_icon=&#8221;off&#8221; icon_color=&#8221;#4d9acf&#8221; use_circle=&#8221;off&#8221; circle_color=&#8221;#4d9acf&#8221; use_circle_border=&#8221;off&#8221; circle_border_color=&#8221;#4d9acf&#8221; icon_placement=&#8221;top&#8221; animation=&#8221;top&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_icon_font_size=&#8221;off&#8221; header_font_size=&#8221;22&#8243; body_font_size=&#8221;14&#8243; use_border_color=&#8221;off&#8221; border_color=&#8221;#4d9acf&#8221; border_style=&#8221;solid&#8221; global_parent=&#8221;301&#8243; header_text_color=&#8221;#ffffff&#8221; border_width=&#8221;2px&#8221; custom_padding=&#8221;40px|40px|40px|40px&#8221; header_line_height=&#8221;1.7em&#8221; body_text_color=&#8221;#ffffff&#8221;]<\/p>\n<ul>\n<li>Nach der Zulassung<\/li>\n<li>Erkennen von seltenen Nebenwirkungen<\/li>\n<li>Vergleich der Wirkung zu anderen Arzneimitteln auf dem Markt, neuer Erkenntnisgewinn in einem sehr gro\u00dfen Patientenkollektiv<\/li>\n<\/ul>\n<p style=\"text-align: center;\">\n<p>[\/et_pb_blurb][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Zeile&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;3_4&#8243;][et_pb_text admin_label=&#8221;Last Update&#8221; global_module=&#8221;1340&#8243; saved_tabs=&#8221;all&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_class=&#8221;content-update&#8221;]<\/p>\n<p><em>Last update: <span class=\"last-modified-timestamp\">01. March 2016 , 11:05<\/span><\/em><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243;][et_pb_sidebar admin_label=&#8221;Seitenleiste&#8221; orientation=&#8221;right&#8221; area=&#8221;et_pb_widget_area_7&#8243; background_layout=&#8221;light&#8221; remove_border=&#8221;off&#8221;]<\/p>\n<p>[\/et_pb_sidebar][\/et_pb_column][\/et_pb_section][et_pb_section admin_label=&#8221;section&#8221; global_module=&#8221;1336&#8243; fullwidth=&#8221;off&#8221; transparent_background=&#8221;off&#8221; background_color=&#8221;#eeeeee&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;on&#8221; padding_mobile=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; gutter_width=&#8221;3&#8243; background_image=&#8221;https:\/\/ngm-cancer.fraujacobi.de\/wp-content\/uploads\/2015\/12\/291_ngm_BG-t5.png&#8221;][et_pb_row global_parent=&#8221;1336&#8243; admin_label=&#8221;row&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; gutter_width=&#8221;3&#8243; padding_mobile=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_equal=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; background_color_1=&#8221;#ffffff&#8221; padding_top_1=&#8221;50px&#8221; padding_right_1=&#8221;32px&#8221; padding_bottom_1=&#8221;50px&#8221; padding_left_1=&#8221;32px&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; background_color_2=&#8221;#ffffff&#8221; padding_top_2=&#8221;50px&#8221; padding_right_2=&#8221;32px&#8221; padding_bottom_2=&#8221;50px&#8221; padding_left_2=&#8221;32px&#8221; parallax_3=&#8221;off&#8221; parallax_method_3=&#8221;off&#8221; background_color_3=&#8221;#ffffff&#8221; padding_top_3=&#8221;50px&#8221; padding_right_3=&#8221;32px&#8221; padding_bottom_3=&#8221;50px&#8221; padding_left_3=&#8221;32px&#8221; column_padding_mobile=&#8221;on&#8221; module_id=&#8221;pseudofooter-row&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_blurb global_parent=&#8221;1336&#8243; admin_label=&#8221;Molekulare Diagnostik&#8221; title=&#8221;Molecular diagnostics&#8221; url_new_window=&#8221;off&#8221; animation=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;center&#8221; icon_placement=&#8221;top&#8221; font_icon=&#8221;%%103%%&#8221; use_icon=&#8221;on&#8221; use_circle=&#8221;off&#8221; use_circle_border=&#8221;off&#8221; icon_color=&#8221;#3b78aa&#8221; circle_color=&#8221;#81d742&#8243; circle_border_color=&#8221;#2caaca&#8221; url=&#8221;\/?p=74\/&#8221; use_icon_font_size=&#8221;off&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; header_line_height=&#8221;1.5em&#8221;]<\/p>\n<p>As the first group in Europe, the Network Genomic Medicine has offered a comprehensive analysis of tumor material since 2012. By means of a multiplex-test in combination with highly sensitive deep sequencing even rare gene mutations in the smallest tissue samples are detected reliably<\/p>\n<p>[\/et_pb_blurb][et_pb_divider global_parent=&#8221;1336&#8243; admin_label=&#8221;Teiler&#8221; color=&#8221;#ffffff&#8221; show_divider=&#8221;off&#8221; divider_style=&#8221;solid&#8221; divider_position=&#8221;top&#8221; divider_weight=&#8221;1&#8243; hide_on_mobile=&#8221;on&#8221; height=&#8221;2&#8243;]<\/p>\n<p>[\/et_pb_divider][et_pb_cta global_parent=&#8221;1336&#8243; admin_label=&#8221;Diagnostik&#8221; button_url=&#8221;\/molekularpathologie\/diagnostik\/&#8221; url_new_window=&#8221;off&#8221; button_text=&#8221;Diagnostik&#8221; use_background_color=&#8221;off&#8221; background_color=&#8221;#4d9acf&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;center&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; custom_button=&#8221;off&#8221; button_text_size=&#8221;16&#8243; button_border_radius=&#8221;0&#8243; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_border_radius_hover=&#8221;0&#8243; button_letter_spacing_hover=&#8221;0&#8243;]<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_blurb global_parent=&#8221;1336&#8243; admin_label=&#8221;Second opinion&#8221; title=&#8221;Second opinion&#8221; url_new_window=&#8221;off&#8221; animation=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;center&#8221; icon_placement=&#8221;top&#8221; font_icon=&#8221;%%86%%&#8221; use_icon=&#8221;on&#8221; use_circle=&#8221;off&#8221; use_circle_border=&#8221;off&#8221; icon_color=&#8221;#3b78aa&#8221; circle_color=&#8221;#999999&#8243; circle_border_color=&#8221;#2caaca&#8221; url=&#8221;\/?p=76\/&#8221; use_icon_font_size=&#8221;off&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; header_line_height=&#8221;1.5em&#8221;]<\/p>\n<p>Do you have questions about your disease or your current therapy? Or maybe you would like to know if for you a personalized treatment approach or immunotherapy might be considered. Please feel free to contact us!<\/p>\n<p>[\/et_pb_blurb][et_pb_divider global_parent=&#8221;1336&#8243; admin_label=&#8221;Teiler&#8221; color=&#8221;#ffffff&#8221; show_divider=&#8221;off&#8221; height=&#8221;32&#8243; divider_style=&#8221;solid&#8221; divider_position=&#8221;top&#8221; divider_weight=&#8221;1&#8243; hide_on_mobile=&#8221;on&#8221;]<\/p>\n<p>[\/et_pb_divider][et_pb_cta global_parent=&#8221;1336&#8243; admin_label=&#8221;Zweitmeinung&#8221; button_url=&#8221;\/?p=76\/&#8221; url_new_window=&#8221;off&#8221; button_text=&#8221;Zweitmeinung&#8221; use_background_color=&#8221;off&#8221; background_color=&#8221;#4d9acf&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;center&#8221; header_font_size=&#8221;26&#8243; body_font_size=&#8221;14&#8243; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; custom_button=&#8221;off&#8221; button_text_size=&#8221;16&#8243; button_border_width=&#8221;2&#8243; button_border_radius=&#8221;0&#8243; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_border_radius_hover=&#8221;0&#8243; button_letter_spacing_hover=&#8221;0&#8243;]<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_blurb global_parent=&#8221;1336&#8243; admin_label=&#8221;Clinical trials&#8221; title=&#8221;Clinical trials&#8221; url_new_window=&#8221;off&#8221; animation=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;center&#8221; icon_placement=&#8221;top&#8221; font_icon=&#8221;%%77%%&#8221; use_icon=&#8221;on&#8221; use_circle=&#8221;off&#8221; use_circle_border=&#8221;off&#8221; icon_color=&#8221;#3b78aa&#8221; circle_color=&#8221;#81d742&#8243; circle_border_color=&#8221;#2caaca&#8221; url=&#8221;\/?p=76\/&#8221; use_icon_font_size=&#8221;off&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; header_line_height=&#8221;1.5em&#8221;]<\/p>\n<p>At the Network Genomic Medicine we try to offer an appropriate clinical trial testing a new drug to all our patients who have a detected mutation, for which there has no drug been approved for treatment yet. For that we work closely together with the Lung Cancer Group Cologne.<\/p>\n<p>[\/et_pb_blurb][et_pb_divider global_parent=&#8221;1336&#8243; admin_label=&#8221;Teiler&#8221; color=&#8221;#ffffff&#8221; show_divider=&#8221;off&#8221; height=&#8221;32&#8243; divider_style=&#8221;solid&#8221; divider_position=&#8221;top&#8221; divider_weight=&#8221;1&#8243; hide_on_mobile=&#8221;on&#8221;]<\/p>\n<p>[\/et_pb_divider][et_pb_cta global_parent=&#8221;1336&#8243; admin_label=&#8221;Studien&#8221; button_url=&#8221;\/?p=78\/&#8221; url_new_window=&#8221;off&#8221; button_text=&#8221;Studien&#8221; use_background_color=&#8221;off&#8221; background_color=&#8221;#4d9acf&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;center&#8221; header_font_size=&#8221;26&#8243; body_font_size=&#8221;14&#8243; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; custom_button=&#8221;off&#8221; button_text_size=&#8221;16&#8243; button_border_width=&#8221;2&#8243; button_border_radius=&#8221;0&#8243; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_border_radius_hover=&#8221;0&#8243; button_letter_spacing_hover=&#8221;0&#8243;]<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Usually drugs or drug combinations which have not yet been approved for the respective disease are tested in clinical trials. Likewise drugs may be tested which, while approved for certain diseases, are not approved for the disease from which patients are suffering in that trial. Trials generally undergo 4 phases. the drug is used in [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":1353,"menu_order":13,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"kontext":[],"_links":{"self":[{"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/pages\/1377"}],"collection":[{"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/comments?post=1377"}],"version-history":[{"count":1,"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/pages\/1377\/revisions"}],"predecessor-version":[{"id":1378,"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/pages\/1377\/revisions\/1378"}],"up":[{"embeddable":true,"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/pages\/1353"}],"wp:attachment":[{"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/media?parent=1377"}],"wp:term":[{"taxonomy":"kontext","embeddable":true,"href":"https:\/\/ngm-cancer.fraujacobi.de\/en\/wp-json\/wp\/v2\/kontext?post=1377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}